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Die klinische Wertigkeit von Biomarkern

Mit Unterstützung klinischer Doktoranden und klinischer interdisziplinärer Kooperationen arbeiten wir an der klinischen und translationalen Wertigkeit von Biomarkern und der Kombination klinischer Untersuchungsbefunde mit Biomarkern, zum Beispiel in der hepatologischen, gastroenterologisch-intensivmedizinischen, kardialen oder hämostaseologisch-gynäkologischen Diagnostik.

Auf der Ebene der klinischen Wertigkeit von Biomarkern können wir auf zahlreiche Publikationen zur translationalen direkten Anwendung in der klinischen Routine und zur Unterstützung, Förderung und Stärkung der Qualität der ärztlichen Entscheidungsfindung am Patienten verweisen.

Originalarbeiten

Erst- und Senior-Autorschaften

  • Yagmur E et al. High serum resistin levels predict poor survival in patients with chronic liver disease. Nature Clin Pract Gastroenterol Hepatol 2006;3:480 (Category research highlight).
  • Yagmur E, Abu Jhaisha S, Buendgens L, Sapundzhieva N, Brozat JF, Hohlstein P, Pollmanns MR, Koek GH, Weiskirchen R, Trautwein C, Tacke F, Wirtz TH, Koch A. Clusterin Plasma Concentrations Are Decreased in Sepsis and Inversely Correlated with Established Markers of Inflammation. Diagnostics. 2022; 12, 3010. https:// doi.org/10.3390/diagnostics12123010; PubMed Central PMCID: PMC9776480.
  • Buendgens L*, Yagmur E*, Ginsberg A, Weiskirchen R, Wirtz T, Abu Jhaisha S, Eisert A, Luedde T, Trautwein C, Tacke F, Koch A. Midregional Proadrenomedullin (MRproADM) Serum Levels in Critically Ill Patients Are Associated with Short-Term and Overall Mortality during a Two-Year Follow-Up. Mediators Inflamm. 2020; 2020: 7184803.  Published online 2020 Aug 7. doi: 10.1155/2020/7184803 PMCID: PMC7428945. *Erstautoren
  • Yagmur E, Sckaer JH, Koek GH, Weiskirchen R, Trautwein C, Koch A, Tacke F. Elevated MRproANP plasma concentrations are associated with sepsis and predict mortality in critically ill patients. J Transl Med. 2019; 17: 415.  Published online 2019 Dec 12. doi: 10.1186/s12967-019-02165-2 PMCID: PMC6909604.
  • Yagmur E, Bast E, Mühlfeld AS, Koch A, Weiskirchen R, Tacke F, Neulen J. High Prevalence of Sticky Platelet Syndrome in Patients with Infertility and Pregnancy Loss. J Clin Med. 2019 Aug 28;8(9). pii: E1328. doi: 10.3390/jcm8091328. PubMed PMID: 31466364; PubMed Central PMCID: PMC6780264.
  • Yagmur E, Otto S, Koek GH, Weiskirchen R, Trautwein C, Koch A, Tacke F. Decreased CTRP3 Plasma Concentrations Are Associated with Sepsis and Predict Mortality in Critically Ill Patients. Diagnostics (Basel). 2019 Jun 21;9(2). pii: E63. doi: 10.3390/diagnostics9020063. PubMed PMID: 31234326; PubMed Central PMCID: PMC6628070.
  • Yagmur E, Buergerhausen D, Koek GH, Weiskirchen R, Trautwein C, Koch A, Tacke F. Elevated CTRP1 Plasma Concentration Is Associated with Sepsis and Pre-Existing Type 2 Diabetes Mellitus in Critically Ill Patients. J Clin Med. 2019 May 11;8(5). pii: E661. doi: 10.3390/jcm8050661. PubMed PMID: 31083558; PubMed Central PMCID: PMC6572622.
  • Yagmur E, Buendgens L, Herbers U, Beeretz A, Weiskirchen R, Koek GH, Trautwein C, Tacke F, Koch A. High mobility group box 1 as a biomarker in critically ill patients. J Clin Lab Anal. 2018 Oct;32(8):e22584. doi: 10.1002/jcla.22584. Epub 2018 Jun 3. PubMed PMID: 29862569; PubMed Central PMCID: PMC6816880.
  • Buendgens L*, Yagmur E*, Bruensing J, Herbers U, Baeck C, Trautwein C, Koch A, Tacke F. Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis. Dis Markers. 2017;2017:5271203. doi: 10.1155/2017/5271203. Epub 2017 Oct 18. PubMed PMID: 29180833; PubMed Central PMCID: PMC5664246. *Erstautoren
  • Bernuth S*, Yagmur E*, Schuppan D, Sprinzl MF, Zimmermann A, Schad A, Kittner JM, Weyer V, Knapstein J, Schattenberg JM, Wörns MA, Galle PR, Zimmermann T. Early changes in dynamic biomarkers of liver fibrosis in hepatitis C virus-infected patients treated with sofosbuvir. Dig Liver Dis. 2016 Mar;48(3):291-7. doi: 10.1016/j.dld.2015.09.015. Epub 2015 Oct 3. PubMed PMID: 26514736. *Erstautoren
  • Yagmur E, Frank RD, Neulen J, Floege J, Mühlfeld AS. Platelet Hyperaggregability is Highly Prevalent in Patients With Chronic Kidney Disease: An Underestimated Risk Indicator of Thromboembolic Events. Clin Appl Thromb Hemost. 2015 Mar;21(2):132-8. doi: 10.1177/1076029613490828. Epub 2013 May 31. PubMed PMID: 23728835.
  • Yagmur E, van Helden J, Koch A, Jadem J, Tacke F, Trautwein C. Effektive Glykolyse-Inhibierung im Citrat-gepufferten venösen Vollblut und Plasma. J Lab Med 2012;36:169-177.
  • Yagmur E, Koch A, Haumann M, Kramann R, Trautwein C, Tacke F. Hyaluronan serum concentrations are elevated in critically ill patients and associated with disease severity. Clin Biochem 2012 Jan;45(1-2):82-7. doi: 10.1016/j.clinbiochem.2011.10.016. Epub 2011 Nov 4. PubMed PMID: 22085533.
  • Yagmur E, Rizk M, Stanzel S, Hellerbrand C, Lammert F, Trautwein C, Wasmuth HE, Gressner AM. Elevation of endoglin concentrations in serum of patients with liver cirrhosis and carcinoma. Eur J Gastroenterol Hepatol 2007 Sep;19(9):755-61. PubMed PMID: 17700260.
  • Yagmur E, Trautwein C, Leers MP, Gressner AM, Tacke F. Elevated apoptosis-associated cytokeratin 18 fragments (CK18Asp386) in serum of patients with chronic liver diseases indicate hepatic and biliary inflammation. Clin Biochem. 2007 Jun;40(9-10):651-5. Epub 2007 Jan 17. PubMed PMID: 17306787.
  • Yagmur E, Weiskirchen R, Gressner AM, Trautwein C, Tacke F. Insulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4. Diabetes Care. 2007 May;30(5):1168-72. Epub 2007 Mar 2. PubMed PMID: 17337499.
  • Poll EM, Kreitschmann-Andermahr I, Langejuergen Y, Stanzel S, Gilsbach JM, Gressner AM, Yagmur E. Saliva collection method affects predictability of serum cortisol. Clin Chim Acta. 2007 Jul;382(1-2):15-9. Epub 2007 Mar 19. PubMed PMID: 17449021.
  • Yagmur, E, Schnyder B, Scholten D, Schirin-Sokhan R, Koch A, Winograd R, Gressner AM, Trautwein C, Wasmuth HE. [Elevated concentrations of fecal
  • calprotectin in patients with liver cirrhosis]. Dtsch Med Wochenschr. 2006 Sep 8;131(36):1930-4. German. PubMed PMID: 16967390.
  • Yagmur E, Driesch R, Gressner AM, Kiefer P. Technical Evaluation of the Beckman Coulter`s OV-Monitor (CA 125 Antigen) Immunoassay. Clin Chem Lab Med. 2006;44(4):420-2. PubMed PMID: 16599835.
  • Yagmur E, Trautwein C, Gressner AM, Tacke F. Resistin serum levels are associated with insulin resistance, disease severity, clinical complications and prognosis in patients with chronic liver diseases. Am J Gastroenterol. 2006 Jun;101(6):1244-52. PubMed PMID: 16771945.
  • Yagmur E, Tacke F, Weiss C, Lahme B, Manns MP, Kiefer P, Trautwein C, Gressner AM. Elevation of Nepsilon-(carboxymethyl)lysine-modified advanced
  • glycation end products in chronic liver disease is an indicator of liver cirrhosis. Clin Biochem. 2006 Jan;39(1):39-45. PubMed PMID: 16321365.
  • Yagmur E. Leberfibrose –Definition, Pathophysiologie und Labor-veränderungen. MTA Dialog 2004;1:28-31.
  • Gressner AM, Yagmur E. Pathogenetic, therapeutic and diagnostic aspects of hepatic fibrosis. J Lab Med 2003;27:423-430.

Co-Autorschaften

  • Hohlstein P, Brozat JF, Schuler J, Abu Jhaisha S, Pollmanns MR, Bündgens L, Wirtz TH, Yagmur E, Hamesch K, Weiskirchen R, Tacke F, Trautwein C, Koch A. Secreted Frizzled Related Protein 5 (SFRP5) Serum Levels Are Decreased in Critical Illness and Sepsis and Are Associated with Short-Term Mortality. Biomedicines. 2023 Jan 22;11(2):313. doi: 10.3390/biomedicines11020313. PMID: 36830849; PMCID: PMC9953555.
  • Puengel T, Weber B, Wirtz TH, Buendgens L, Loosen SH, Geisler L, Özdirik B, Hamesch K, Jhaisha SA, Brozat JF, Hohlstein P, Eisert A, Yagmur E, Trautwein C, Tacke F, Koch A. Low Serum Levels of Soluble Receptor Activator of Nuclear Factor ? B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill Patients. Diagnostics. 2021 Dec 28;12(1):62. doi: 10.3390/diagnostics12010062. Pubmed PMID: 35054232
  • Hamesch K, Mandorfer M, Pereira VM, Moeller LS, Pons M, Dolman GE, Reichert MC, Heimes CV, Woditsch V, Voss J, Lindhauer C, Fromme M, Spivak I, Guldiken N, Zhou B, Arslanow A, Schaefer B, Zoller H, Aigner E, Reiberger T, Wetzel M, Siegmund B, Simões C, Gaspar R, Maia L, Costa D, Bento-Miranda M, van Helden J, Yagmur E, Bzdok D, Stolk J, Gleiber W, Knipel V, Windisch W, Mahadeva R, Bals R, Koczulla R, Barrecheguren M, Miravitlles M, Janciauskiene S, Stickel F, Lammert F, Liberal R, Genesca J, Griffiths WJ, Trauner M, Krag A, Trautwein C, Strnad P; European Alpha1-Liver Study Group. Liver Fibrosis and Metabolic Alterations in Adults with Alpha1 Antitrypsin Deficiency Caused by the Pi*ZZ Mutation. Gastroenterology. Sep;157(3):705-719.e18. doi: 10.1053/j.gastro.2019.05.013. Epub 2019 May 20. PubMed PMID: 31121167.
  • Koch A, Weiskirchen R, Krusch A, Bruensing J, Buendgens L, Herbers U, Yagmur E, Koek GH, Trautwein C, Tacke F. Visfatin Serum Levels Predict Mortality in Critically Ill Patients. Dis Markers. 2018 Aug 26;2018:7315356. doi: 10.1155/2018/7315356. eCollection 2018. PubMed PMID: 30224938. PubMed Central; PMCID: PMC6129328.
  • Koch A, Yagmur E, Linka J, Schumacher F, Bruensing J, Buendgens L, Herbers U, Koek GH, Weiskirchen R, Trautwein C, Tacke F. High Circulating Caspase-Cleaved Keratin 18 Fragments (M30) Indicate Short-Term Mortality in Critically Ill Patients. Dis Markers. 2018 Jul 8;2018:8583121. doi: 10.1155/2018/8583121. eCollection 2018. PubMed PMID: 30069276; PubMed Central PMCID: PMC6057335.
  • Koch A, Yagmur E, Hoss A, Buendgens L, Herbers U, Weiskirchen R, Koek GH, Trautwein C, Tacke F. Clinical relevance of copeptin plasma levels as a biomarker of disease severity and mortality in critically ill patients. J Clin Lab Anal. 2018 Nov;32(9):e22614. doi: 10.1002/jcla.22614. Epub 2018 Jul 5. PubMed PMID: 29974524; PubMed Central PMCID: PMC6817249.
  • Shirvani-Dastgerdi E, Winer BY, Celià-Terrassa T, Kang Y, Tabernero D, Yagmur E, Rodríguez-Frías F, Gregori J, Luedde T, Trautwein C, Ploss A, Tacke F. Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy. J Hepatol. 2017 Aug;67(2):246-254. doi: 10.1016/j.jhep.2017.03.027. Epub 2017 Apr 7. PubMed PMID: 28392234; PubMed Central PMCID: PMC6016549.
  • Buendgens L, Yagmur E, Bruensing J, Herbers U, Baeck C, Trautwein C, Koch A, Tacke F. C-terminal proendothelin-1 (CT-proET-1) is associated with organ failure and predicts mortality in critically ill patients. J Intensive Care. 2017 Mar 20;5:25. doi: 10.1186/s40560-017-0219-y. eCollection 2017. PubMed PMID: 28331622; PubMed Central PMCID: PMC5359904.
  • Mueller S, Nahon P, Rausch V, Peccerella T, Silva I, Yagmur E, Straub BK, Lackner C, Seitz HK, Rufat P, Sutton A, Bantel H, Longerich T. Caspase-cleaved keratin-18 fragments increase during alcohol withdrawal and predict liver-related death in patients with alcoholic liver disease. Hepatology. 2017 Jul;66(1):96 107. doi: 10.1002/hep.29099. Epub 2017 May 9. PubMed PMID: 28170108.
  • Rausch V, Peccerella T, Lackner C, Yagmur E, Seitz HK, Longerich T, Mueller S. Primary liver injury and delayed resolution of liver stiffness after alcohol detoxification in heavy drinkers with the PNPLA3 variant I148M. World J Hepatol. 2016 Dec 18;8(35):1547-1556. doi: 10.4254/wjh.v8.i35.1547. PubMed PMID: 28050235; PubMed Central PMCID: PMC5165268.
  • Koch A, Weiskirchen R, Ludwig S, Buendgens L, Bruensing J, Yagmur E, Baeck C, Herbers U, Trautwein C, Tacke F. Relevance of serum sclerostin concentrations in critically ill patients. J Crit Care. 2017 Feb;37:38-44. doi: 10.1016/j.jcrc.2016.08.019. Epub 2016 Aug 22. PubMed PMID: 27621111.
  • Bruns T, Nuraldeen R, Mai M, Stengel S, Zimmermann HW, Yagmur E, Trautwein C, Stallmach A, Strnad P. Low serum transferrin correlates with acute-on-chronic organ failure and indicates short-term mortality in decompensated cirrhosis. Liver Int. 2017 Feb;37(2):232-241. doi: 10.1111/liv.13211. Epub 2016 Aug 17. PubMed PMID: 27473364.
  • Sadeghi A, Shirvani-Dastgerdi E, Tacke F, Yagmur E, Poortahmasebi V, Poorebrahim M, Mohraz M, Hajabdolbaghi M, Rasoolinejad M, Abbasian L, Jafari R, Fakhari Z, Norouzi M, Ebrahimian A, Geravand B, Alavian SM, Jazayeri SM. HBsAg mutations related to occult hepatitis B virus infection in HIV-positive patients result in a reduced secretion and conformational changes of HBsAg. J Med Virol. 2017 Feb;89(2):246-256. doi: 10.1002/jmv.24623. Epub 2016 Aug 1. PubMed PMID: 27381922.
  • Shirvani-Dastgerdi E, Pourkarim MR, Herbers U, Amini-Bavil-Olyaee S, Yagmur E, Alavian SM, Trautwein C, Tacke F. Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro. Clin Microbiol Infect. 2016 Jan;22(1):98.e1-6. doi: 10.1016/j.cmi.2015.09.020. Epub 2015 Oct 30. PubMed PMID: 26433026.
  • Asimakopoulou A, Borkham-Kamphorst E, Henning M, Yagmur E, Gassler N, Liedtke C, Berger T, Mak TW, Weiskirchen R. Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver. Biochim Biophys Acta. 2014 Oct;1842(10):1513-24. doi: 10.1016/j.bbalip.2014.07.017. Epub 2014 Jul 31. PubMed PMID: 25086218.
  • Tacke F, Galm O, Kanig N, Yagmur E, Brandt S, Lindquist JA, Eberhardt CS, Raffetseder U, Mertens PR. High prevalence of Y-box protein-1/p18 fragment in plasma of patients with malignancies of different origin. BMC Cancer. 2014 Jan 20;14:33. doi: 10.1186/1471-2407-14-33. PubMed PMID: 24443788; PubMed Central PMCID: PMC3909385.
  • Koch A, Zimmermann HW, Baeck C, Schneider C, Yagmur E, Trautwein C, Tacke F. Serum NT-proCNP concentrations are elevated in patients with chronic liver diseases and associated with complications and unfavourable prognosis of cirrhosis. Clin Biochem. 2012 Apr;45(6):429-35. doi: 10.1016/j.clinbiochem.2012.01.009. Epub 2012 Jan 18. PubMed PMID: 22285383.
  • Koch A, Horn A, Dückers H, Yagmur E, Sanson E, Bruensing J, Buendgens L, Voigt S, Trautwein C, Tacke F. Increased liver siffness denotes hepatic dysfunction and mortality risk in critically ill non-cirrhotic patients at a medical ICU. Crit Care. 2011;15(6):R266. doi: 10.1186/cc10543. Epub 2011 Nov 14. PubMed PMID: 22082207; PubMed Central PMCID: PMC3388655.
  • Koch A, Voigt S, Kruschinski C, Sanson E, Dückers H, Horn A, Yagmur E, Zimmermann HW, Trautwein C, Tacke F. Circulating soluble urokinase plasminogen activator receptor is stably elevated within the first week of treatment in the ICU and predicts mortality in critically ill patients. Crit Care. 2011;15(1):R63. doi: 10.1186/cc10037. Epub 2011 Feb 16. PubMed PMID: 21324198; PubMed Central PMCID: PMC3221996.
  • Berres ML, Schnyder B, Yagmur E, Inglis B, Stanzel S, Tischendorf JJ, Koch A, Winograd R, Trautwein C, Wasmuth HE. Longitudinal monocyte human leukocyte antigen-DR expression is a prognostic marker in critically ill patients with decompensated liver cirrhosis. Liver Int. 2009 Apr;29(4):536-43. doi: 10.1111/j.1478-3231.2008.01870.x. Epub 2008 Sep 15. PubMed PMID: 18795898.
  • Schlieper G, Hristov M, Brandenburg V, Krüger T, Westenfeld R, Mahnken AH, Yagmur E, Boecker G, Heussen N, Gladziwa U, Ketteler M, Weber C, Floege J. Predictors of low circulating endothelial progenitor cell numbers in haemodialysis patients. Nephrol Dial Transplant. 2008 Aug;23(8):2611-8. doi: 10.1093/ndt/gfn103. Epub 2008 Mar 19. PubMed PMID: 18353889.
  • Kreitschmann-Andermahr I, Poll EM, Reineke A, Langejürgen Y, Yagmur E, Gilsbach JM, Saller B. Diagnosing neuroendocrine dysfunction in patients after aneurysmal subarachnoid hemorrhage in clinical practice – does basal hormone screening make sense? Exp Clin Endocrinol Diabetes. 2008 May;116(5):276-81. PubMed PMID: 18589891.
  • Blindt R, Stellbrink K, de Taeye A, Müller R, Kiefer P, Yagmur E, Weber C, Kelm M, Hoffmann R. The significance of vasodilator-stimulated phosphoprotein for risk stratification of stent thrombosis. Thromb Haemost. 2007 Dec;98(6):1329-34. PubMed PMID: 18064332.
  • Tischendorf JJ, Yagmur E, Scholten D, Vidacek D, Koch A, Winograd R, Gressner AM, Trautwein C, Wasmuth HE, Lammert F. The interleukin-6 (IL6)-174 G/C promoter genotype is associated with the presence of septic shock and the ex vivo secretion of IL6. Int J Immunogenet. 2007 Dec;34(6):413-8. PubMed PMID: 18001296.
  • Delanghe JR, Helander A, Wielders JPM, Pekelharing JM, Roth HJ, Schellenberg F, Born C, Yagmur E, Gentzer W, Althaus H. Development and Multicenter Evaluation of the N Latex CDT Direct Immunonephelometric Assay for Serum Carbohydrate-Deficient Transferrin. Clin Chem. 2007 Jun;53(6):1115-21. Epub 2007 Apr 5. PubMed PMID: 17412797.
  • Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R, Brenner DA, Schnabl B. Upregulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. J Gastroenterol Hepatol. 2007 Aug;22(8):1256-64. PubMed PMID: 17688666.
  • Gressner AM, Yagmur E, Lahme B, Gressner O, Stanzel S. Connective Tissue Growth Factor in Serum as a New Candidate Test for Assesment of Hepatic Fibrosis. Clin Chem. 2006 Sep;52(9):1815-7. Epub 2006 Jul 20. PubMed PMID: 16858074.
  • Wasmuth HE, Kunz D, Yagmur E, Timmer-Stranghöner A, Vidacek D, Siewert E, Bach J, Geier A, Purucker EA, Gressner AM, Matern S, Lammert F. Patients with acute on chronic liver failure display sepsis-like immune paralysis. J Hepatol. 2005 Feb;42(2):195-201. PubMed PMID: 15664244.

Case reports

  • Yagmur E, Weiskirchen R, Schedel A, Bugert P. PTGS1 compound heterozygosity impairs gene expression and platelet aggregation and is associated with severe bleeding complications. Thromb Haemost. 2013 Nov;110(5):1083-5. doi: 10.1160/TH13-02-0110. Epub 2013 Sep 5. PubMed PMID: 24008976.
  • Hütten M, Kohne E, Yagmur E, Schaible T, Wenzl T, Wagner N, Heimann K. Persistent cyanosis in a 4 month old infant with severe pneumonia and haemoglobin M. Klin Padiatr. 2009 Sep;221(5):305-7. doi: 10.1055/s-0028-1104597. Epub 2009 Feb 6. PubMed PMID: 19199228.
  • Schoberer A, Yagmur E, Boltshauser E, Korinth M, Niggemann P, Häusler M. Sub-aponeurotic fluid collections: A delayed-onset self-limiting cerebrospinal fluid fistula in young infants. Eur J Paediatr Neurol. 2008 Sep;12(5):401-3. Epub 2007 Dec 3. PubMed PMID: 18061497.
  • Yagmur E, Piatkowski A, Gröger A, Pallua N, Gressner AM, Kiefer P. Bleeding complication under Gingko biloba medication. Am J Hematol. 2005 Aug;79(4):343-4. PubMed PMID: 16044448.

Buchkapitel

  • Yagmur E. Klinikhandbuch – Labordiagnostische Pfade. DeGruyter 2012. Hrsg.: W. Hofmann, J. Aufenanger, G. Hoffmann. Buchbeitrag Kapitel: Extravasalflüssigkeiten.
  • Hofmann W, Aufenanger J, Hoffmann G (Hrsg.): Klinikhandbuch Labordiagnostische Pfade | Einführung – Screening – Stufendiagnostik, 2. Auflage. Berlin: Verlag Walter de Gruyter, 2014.